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I have no evidence except my own experience, but the shorter regional flights seem better by nearly every measure. For example, I've flown from O'Hare to Greenville, SC on United Express (Mesa) twice recently, and all legs of those flights were on time. There were no hassles on the ground and service in the air was good. I've had more problems with regular business flights to and from O'Hare and LaGuardia on United and American - mainly supposed weather-related delays and poor communication.
So I agree with other posters that it seems unfair to blame the regional jets. Recent articles in mainstream papers have noted the almost criminal downsizing by the major airlines in their efforts to keep prices low and turn a profit. I want well paid employees--and plenty of them--attending to my safety, and I'm willing to pay much more for it. Yes, even 4x!