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"Republicans can pretend that nothing has really changed, that this is still a 'center-right' nation, and that only an ill-timed economic meltdown cost them the White House" -- then GOD BLESS THE ECONOMIC MELTDOWN.
It would stand as proof of the old saying about an ill wind blowing no good -- an odd phrase, when you get down to analyzing it, but it means almost ANY disaster can have an unexpected good result rising out of the ashes.
This would be a prime example -- if it took the Wall Street debacle to finally displace the destructive Republican Party, then let's consider at least THAT much of the disaster to be beneficial.