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For crying out loud, we've had a two-term (male) president who looks like a chimpanzee. It doesn't seem to have hurt his electability any.
If Clinton has a not un-chipmunkish look about her when she's in a genuine good humor, fine. Do we really require of female politicians that they look like models?
Give me a politician, male or female, who is sincere and funny-looking over beautiful and false any day.