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While safer injecting sites are one approach to harm reduction among IDUs, there are other approaches which may be more acceptable in the conservative climate of the US. San Francisco's ISIS clinic for soft tissue infections has saved the city a considerable amount of money (over and above the operating costs of the clinic) while providing high quality medical care and referrals to treatment. Narcan distribution programs are showing promise in reducing overdose deaths. It is worth noting that safer injecting sites are not the only way to reduce morbidity and mortality among IDUs. It would have been nice if the article had briefly highlighted some of the other innovative harm reduction measures currently being implemented.