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The biological imperative to survive by 1) reproduction and 2) social acceptance, is awfully damned powerful.
But today I make the same argument made by those who champion birth control, since by all accounts our world is currently struggling to support more humans than has ever been in existence on the planet... World population has more than doubled in my lifetime alone, and to begin with there were more than enough humans to perpetuate the species. It might be a good idea to start looking past our notions of what's required to be a valuable human being.
Reproduction, while a foundational force, is obviously not the main benefit to human life at this point. In fact, as far as the planet is concerned, we're approaching the status of being more like a deadly virus.
Socially, we're at the point of self destruction if we don't get wise to more compassionate and flexible approaches to our fellow human beings. No joke if you look at national and religious extremists, some with histories of fighting and grudge holding for thousands of years, now having nuclear weapons.
So from a very objective point of view, Mr. Callahan makes an awfully good point - at least in the U.S. we'd be wise to become more inclusive in society and expand our definition of what it is to be human... not just male or female and heterosexual.
From a spiritual point of view, if one believes in a Creator - God or Allah or Yaweh or any other powerful creative and spiritual being - It's impossible for anything in the universe to have been created outside the spiritual and natural order. What's been lacking in the natural order is our acceptance of those who are more than physically unique than we're accustomed to.
We have no right to try and trump the Creator's card by passing judgment and excluding those with whom we are not personally familiar.
As global communication and travel continues, I imagine we're only going to continue struggling with this lesson until we learn it.