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Ask ten random non-runners who's going to win any given marathon, and you'll get back the answer, "Probably some guy from Kenya."
The perception that most Americans are laboring under a profound genetic disadvantage when it comes to distance running is what's responsible for the lack of serious American-born competitors. It's not Oprah's fault.
After all, the hordes of amateurs in other sports don't prevent serious competitors from going for the gold.