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To LW: Guardianship is not the same as a will. Bequeathing your estate is an easy choice; guardianship is really tough. You could get your lawyer to draft a separate document, and update it as you need to. Everybody's life will be changing all the time--your sister, your friends. You can't anticipate any of that future, or what it would mean for your kids--you can only make the choice that feels most appropriate at the moment. And adjust it as life unfolds. But the "blood" argument doesn't hold up--it seems like at any given moment you should choose people who will raise your kids in an environment that you would want for them. Won't your family be there for them anyway?