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It sounds like the wife is a selfish, controlling person who wants him to stop taking a medication that is obviously helping him greatly simply so that she can regain her previous control over the relationship.
Why else hardly ever have sex, primarily use it as a bargaining and emotional lever, then make a big fuss when the other party loses interest?
It is no simple trick to find a medication that will help someone's depression as much as he has been helped by Celexa...speaking from experience. Since she claims her feelings about sex have changed, it sounds like she knew good and well that she was unfairly manipulating the husband and now is scrambling to mop up. Can she be sincere? Maybe. But even if she is, the issue remains that she is probably a pretty screwy person to have done that kind of crap in the first place, and often people don't change much even when they want to.
If I were the LW, I would stay on the medication that is helping me so much, and use my new mental/emotional clarity and lack of interest in sex to seriously examine my feelings about the relationship. It appeared that there wasn't much to the marriage besides the occasional sex for the LW, and it's quite possible that he would be much better off away from his wife. If children are involved, of course that also requires consideration - but it sounds to me that he has discovered that there really isn't anything there worth having.
