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you should go down at least two sizes. As a former 38Der, I sure did. I wear a 36C now and feel that it's about right--I could wear a B1/2 if I bought that brand that does half sizes.
Kids and aging change a lot, but I actually look better now than I did earlier. I think I'm the only woman in the world who's very happy with her breasts.
Too big, too small, too saggy--I've dodged 'em all. Lucky me. But I know women who didn't nurse because they were afraid of ruining their breasts (granted, they are older).
Nurse your kids, ladies. The post nursing droop is not inevitable either--it didn't happen to me.