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Different sub-types of HIV have been implicated vis a vis differing transmission vectors, ease of transmission, and in some cases, the progression of disease. Some sub-types more prevalent in Africa appear to be more amenable to transmission via heterosexual intercourse.
http://www.avert.org/hivtypes.htm
http://pathmicro.med.sc.edu/lecture/hiv6.htm
http://www.hopkinsmedicine.org/Press_releases/2006/02_06_06.html
As far as being sans foreskin, would my brain actually explode during orgasm were I so fortunate as to have retained mine?