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No one seems to remember Janis Karpinski, a woman, was in charge of Abu Ghraib prison while atrocities were being committeed right under her nose. Oh right, she was a victim, and has no real responsibility for what happened under her watch.
And aside from Thatcher, women along the lines of Biljana Plavsic were not too uncommon to find during the Bosnian war. She succeeded Karadzic as president after the 1995 Dayton peace accord, and was charged with every crime in its statute: genocide, war crimes, crimes against humanity and grave breaches of the Geneva Conventions. Plavsic joined Karadzic in rejecting the idea of a multiethnic Bosnia, fueling the 1992-1995 conflict. Throughout the war, Plavsic backed Serb purges of other ethnic groups, was seen visiting troops at the front, and became know as the Mother of Ethnic Cleansing.