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I can think of a few instances where parents might need to take a baby on a long flight--relocating, or visiting family, for instance, but I'm just curious--how many people take overseas vacations and decide they shouldn't have to alter their pre-kid lifestyle to see the Louvre? That trend has been increasing in past years.
I think if you have to ask yourself whether you should sedate your kid for a trip, you should probably ask whether your kid is too young to be making this kind of trip in the first place and, given the circumstances, how important it is. Great-grandparents in Budapest who won't be around when the kid is old enough to sit quietly--OK, makes sense. But you can visit London some other time.
And, by the way, I'm someone who's extremely sympathetic to fellow travelers too young to clear their own Eustachian tubes.