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Unchecked clinical depression is a dark sinking hole that causes the sufferer see the world as an alien and hostile place and, yes, if it continues its trajectory it leaves that soul with only one sane choice--self destruction. To add things like "accusation" and "rage" on the part of the sufferer to the discussion is, to me, extraordinarily beyond the point, so much so, as to be trivial. This is something bigger and more insidious than that. I suspect that people as bright as Wallace and Lukas tried to fight their dark, out of control thoughts with that intellect. Sadly, such a strategy has rarely if ever worked. And it is why you will find some of the most haunted and depressed people are also the most intelligent and sensitive. They place too much of a premium on this intelligence...but no intellect has that capacity. And that, for you people who rate humans on intellect, should be humbling.